With growing number of applications relying on complex simulations in areas ranging from science to engineering design, there is a need for algorithms and software implementations that can effectively optimize simulation output with minimal computational efforts. Our w...

We study the production of biobased chemicals from the viewpoint of process systems engineering, we perform techno-economic analysis and LCA and eventually achieve the optimal framework of biorefineries. Read more.

Economic analysis can provide preliminary cost assessment for industrial process at the design stage. In recent years, continuous biopharmaceutical process has become increasingly popular due to its advantages in flexibility, product quality, productivity, and profitab...

Multiple modeling approaches exist and continue to advance in the field of pharmaceutical manufacturing that resulted from the need to shift to continuous processing. While there are pros and cons for the various modeling methodologies, we strive to develop hybrid appr...

We work on the integration of decision-making across different scales: from process control to supply chain management. Read more.

This work aims to develop an efficient integrated methodology that enables an in-depth process understanding based on simulation for pharmaceutical manufacturing processes. 

Biopharmaceuticals was once a scientific exploration but now, with global revenue of more than $160 billion, it is a business mainstream growing at the annual rate of 8%. An industry thriving at this pace needs faster and more reliable tools for option ranking and alte...

Feeding accuracy is of great importance in continuous processes given the stringent requirements for product composition. In this webinar we discuss the development of semi-empirical models for feeder behavior using material properties as input parameters. This work is...

We work on the development of simulation-based optimization methodologies for SCM that incorporate more detailed SC dynamics resulting from individual decision-making of the different entities in the SC network.