2018

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• Wang, Z., Ierapetritou, M. Global sensitivity, feasibility, and flexibility analysis of continuous pharmaceutical manufacturing processes. Computer Aided Chemical Engineering, 41, 189-213, 2018.

• Sampat, C., Bettencourt, F., Baranwal, Y., Paraskevakos, I., Chaturbedi, A.,  Karkala, S., Jha, S., Ramachandran, R., Ierapetritou, M. A parallel unidirectional coupled DEM-PBM model for the efficient simulation of computationally intensive particulate process systems. Computers & Chemical Engineering, 119, 128-142, 2018.

• Escotet-Espinoza, M.S., Moghtadernejad, S., Scicolone, J., Wanh, Y., Pereira, G., Schafer, E., Vigh, T., Klingeleers, D., Ierapetritou, M., Muzzio, F.J. Using a material property library to find surrogate materials for pharmaceutical process development. Powder Technology, DOI: doi.org/10.1016/j.powtec.2018.08.042

• Metta, N., Verstraeten, M.,Ghijs, M., Kumar, A., Schafer, E., Singh, R., De Beer, T., Nopens, I., Cappuyns, P., Assche, I., Ierapetritou, M., Ramachandran, R. Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process. International Journal of Pharmaceuticals, 549(1-2), 271-282, 2018.

• Wang, Z. Ierapetritou, M. Constrained optimization of black-box stochastic systems using a novel feasibility enhanced Kriging-based method. Computers and Chemical Engineering, doi.org/10.1016/j.compchemeng.2018.07.016.

• Escotet-Espinoza, M.S., Foster, C.J., Ierapetritou, M. Discrete Element Modeling (DEM) for mixing of cohesive solids in rotating cylinders. Powder Technology, 335, 124-136, 2018.

• Farzan, P., Ierapetritou, M.G. A Framework for the Development of Integrated and Computationally Feasible Models of Large-Scale Mammalian Cell Bioreactors. Processes 6 (7), 82, 2018.

• Escotet-Esponoza, MS., Vadodaria, S. Muzzio, FJ., Ierapetritou, MG. Modeling the Effects of Material Properties on Tablet Compaction: A building block for controlling both batch and continuous pharmaceutical manufacturing processes. International Journal of Pharmaceutics, 543 (1-2), 274-287, 2018

• Cao, H., Mushnoori, S., Higgins, B., Kollipara, C., Fermier, A., Hausner, D., Jha, S., Singh, R., Ierapetritou, M, Ramachandran, R. A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line. Processes, 6(5), 53, 2018.

• Dias, L.S., Pattison, R.C., Tsay, C., Baldea, M., Ierapetritou, M.G. A Simulation-based Optimization Framework for Integrating Scheduling and Model Predictive Control, and its Application to Air Separation Units. Computers and Chemical Engineering, 113, 139-151, 2018.

• Bano,G., Wang, Z., Facco, P., Bezzo, F., Barolo, M., Ierapetritou, M. A novel and systematic approach to identify the design space of pharmaceutical processes. Computers and Chemical Engineering, 115, 309-322, 2018.

• Metta, N., Ierapetritou, M., Ramachandran, R. A multiscale DEM-PBM approach for a continuous comilling process using a mechanistically developed breakage kernel. Chemical Engineering Science 178, 211-221, 2018.

• Bhosekar, A. Ierapetritou, M. Advances in surrogate based modeling, feasibility analysis, and optimization: A review. Computers and Chemical Engineering, 108, 250-267, 2018.

• Pereira, G.C., Muddu, S.V., Román-Ospino, A.D., Clancy, D., Igne, B., Airiau, C., Muzzio, F.J., Ierapetritou, M., Ramachandran, R., Singh, R. Combined feedforward/feedback control of an integrated continuous granulation process. Journal of Pharmaceutical Innovation, DOI: https://doi.org/10.1007/s12247-018-9347-8

• Sampat, C., Baranwal, Y., Paraskevakos, I., Jha, S., Ierapetritou, M., Ramachandran, R. HPC enabled parallel, multi-scale & mechanistic model for high shear granulation using a coupled DEM-PBM framework. Computer Aided Chemical Engineering, 44, 1459-1464, 2018.

• Bano, G., Wang, Z., Facco, P., Bezzo, F., Barolo, M., Ierapetritou, M. Dimensionality reduction in feasibility analysis by latent variable modeling. Computer Aided Chemical Engineering, 44, 1477-1482, 2018.

• Bhosekar, A., Ierapetritou, M. Space mapping based derivative-free optimization framework for supply chain optimization. Computer Aided Chemical Engineering, 44, 985-990, 2018.

• Wang, Z. Ierapetritou, M. Surrogate-based feasibility analysis for black-box stochastic simulations with heteroscedastic noise. Journal of Global Optimization, 71, 957-985, 2018.

• Ierapetritou, M. Wang, Z. Modelling and its Applications in Solids-based Continuous Pharmaceutical Manufacturing Processes. Pharma Focus Asia, 2018.